oxysterol
Sign in to saveAlso known as oxysterols
An oxysterol is a derivative of cholesterol obtained by oxidation involving enzymes and / or pro-oxidants. Such compounds play important roles in various biological processes such as cholesterol homeostasis, lipid metabolism (sphingolipids, fatty acids), apoptosis, autophagy, and prenylation of proteins; the mode of action of oxysterols in these effects is still poorly understood. Several oxysterols are associated with age-related diseases such as cardiovascular disease, eye disease (cataract, age-related macular degeneration), certain neurodegenerative diseases and cancers. Identifying thera
In the Vinony graph
Vinony's link graph records 37 inbound references to oxysterol, and connects out to enzyme, Alzheimer's disease and Parkinson's disease.
It is catalogued under the topic Sterols.
Vinony links it to 7 Wikipedia language editions.
Research
5,946 papers- Oxysterol research: a brief review.Biochemical Society transactions · 2019
- Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension.Circulation research · 2024
- Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.Cell · 2017
- Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2023
- The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
via PubMed
~6 min read
Encyclopedic overview
10 sectionsContents
- Measurement
- Sources
- Types
- Biological activities
- Disease relevance
- Cardiovascular and metabolic disorders
- Nervous system
- Cancer
- Example
- References
An oxysterol is a derivative of cholesterol obtained by oxidation involving enzymes and / or pro-oxidants. Such compounds play important roles in various biological processes such as cholesterol homeostasis, lipid metabolism (sphingolipids, fatty acids), apoptosis, autophagy, and prenylation of proteins; the mode of action of oxysterols in these effects is still poorly understood. Several oxysterols are associated with age-related diseases such as cardiovascular disease, eye disease (cataract, age-related macular degeneration), certain neurodegenerative diseases and cancers. Identifying therapies to regulate the body's production of oxysterols and their biological activities is of therapeutic interest.
A wider definition could encompass oxidized phytosterols, which are also sterols. The term "oxyphytosterols" may be used for distinction.
Excerpted from Wikipedia’s “oxysterol” article, available under the CC BY-SA 4.0 licence.