PAPPA2
Sign in to saveAlso known as PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2, SSDA
Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.
Gene data
PAPPA2- Name
- pappalysin 2
- Type
- protein-coding
- Position
- 176,463,171–176,845,601 (+)
- Aliases
- PAPP-A2, PAPP-E, PAPPE, PLAC3, SSDA
- Ensembl
- ENSG00000116183
- RefSeq RNA
- NM_020318.3, NM_021936.3, XM_005245422.4, XM_011509857.1, XM_017002023.2
- RefSeq protein
- NP_064714.2, NP_068755.2, XP_005245479.1, XP_011508159.1, XP_016857512.1
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pappalysin 2
- Symbol
- PAPPA2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:176,463,171-176,845,601
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 10661
- exact match
- identifiers.org/ncbigene/60676
- genomic end
- 176845601
- genomic start
- 176432307
- cytogenetic location
- 1q25.2
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.
==References==