Structure via PubChem · Public domain (PubChem)
phenadoxone
Sign in to savePhenadoxone (trade names Heptalgin, Morphidone, and Heptazone) is an opioid analgesic of the open chain class (methadone and relatives) invented in Germany by Hoechst in 1947. It is one of a handful of useful synthetic analgesics which were used in the United States for various lengths of time in the 20 or so years after the end of the Second World War but which were withdrawn from the market for various or no known reason and which now are mostly in Schedule I of the United States' Controlled Substances Act of 1970, or (like phenazocine and bezitramide) in Schedule II but not produced or mark
In the Vinony graph
Within Vinony's link graph, phenadoxone is referenced by 276 other articles, and connects out to (+)-catechin, butorphanol and prodine.
It sits within the topics 4-Morpholinyl compounds, Benzhydryl compounds and Chemical pages without DrugBank identifier.
Its subject is documented across 8 Wikipedia language editions.
Chemical data
- Formula
- C23H29NO2
- Molecular weight
- 351.5 g/mol
- IUPAC name
- 6-morpholin-4-yl-4,4-diphenylheptan-3-one
- SMILES
- CCC(=O)C(CC(C)N1CCOCC1)(C2=CC=CC=C2)C3=CC=CC=C3
- InChIKey
- LOXCOAXRHYDLOW-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 351.22
Show 3 more facts
- chemical formula
- C₂₃H₂₉NO₂
- canonical SMILES
- CCC(=O)C(CC(C)N1CCOCC1)(C2=CC=CC=C2)C3=CC=CC=C3
- Commons category
- Phenadoxone
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
Phenadoxone (trade names Heptalgin, Morphidone, and Heptazone) is an opioid analgesic of the open chain class (methadone and relatives) invented in Germany by Hoechst in 1947. It is one of a handful of useful synthetic analgesics which were used in the United States for various lengths of time in the 20 or so years after the end of the Second World War but which were withdrawn from the market for various or no known reason and which now are mostly in Schedule I of the United States' Controlled Substances Act of 1970, or (like phenazocine and bezitramide) in Schedule II but not produced or marketed in the US. Others on this list are ketobemidone (Ketogin), dextromoramide (Dimorlin, Palfium and others), phenazocine (Narphen and Prinadol), dipipanone (Diconal, Pipadone and Wellconal), piminodine (Alvodine), propiram (Algeril), anileridine (Leritine) and alphaprodine (Nisentil).
Phenadoxone has a US DEA ACSCN of 9637 and has had a zero annual manufacturing quota under the Controlled Substances Act 1970. Its withdrawal from US distribution prior to the promulgation of said act is a large part of its Schedule I designation; it is, however, used as a legitimate medication in other countries and consumption is increasing worldwide as indicated below.
Excerpted from Wikipedia’s “phenadoxone” article, available under the CC BY-SA 4.0 licence.