Structure via PubChem · Public domain (PubChem)
piracetam
Sign in to savePiracetam is a drug that has efficacy in cognitive disorders, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia; sources differ on its usefulness for dementia. Piracetam is sold as a medication in many European countries. Piracetam in the United States is not approved for general use.
Chemical data
- Formula
- C6H10N2O2
- Molecular weight
- 142.16 g/mol
- IUPAC name
- 2-(2-oxopyrrolidin-1-yl)acetamide
- SMILES
- C1CC(=O)N(C1)CC(=O)N
- InChIKey
- GMZVRMREEHBGGF-UHFFFAOYSA-N
- XLogP
- -1.3
- Polar surface area
- 63.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
4,017 papers- Efficacy of piracetam in children with breath-holding spells: a systematic review and meta-analysis.European journal of pediatrics · 2024
- Cognitive effects of piracetam in adults with memory impairment: A systematic review and meta-analysis.Clinical neurology and neurosurgery · 2024
- The mechanistic role of piracetam in the management of vascular dementia.Behavioural brain research · 2025
- Piracetam as Neuroprotective, Anticonvulsant, and Anti-Anxiety Agent: An In Vivo Study on Ptz Epileptic Rats.Archives of Razi Institute · 2024
- Piracetam--an old drug with novel properties?Acta poloniae pharmaceutica · 2005
via PubMed
Described at
Piracetam: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
Learn more about Piracetam uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Piracetam.
webmd.com →People commonly use piracetam for breath-holding attacks, epilepsy , dizziness, dyslexia, surgery to improve blood flow to the heart , and a movement disorder often caused by antipsychotic drugs (tardive dyskinesia ). It is also used for Alzheimer disease , autism, dementia , depression , memory, schizophrenia, sickle cell disease , and many other conditions, but there is no good scientific evidence to support these uses. Breath-holding attacks . Taking piracetam by mouth reduces breath-holding attacks in young children. Surgery to improve blood flow to the heart (CABG surgery) . Taking piracetam by mouth or by IV around the time of CABG surgery helps with memory and thinking skills after surgery. IV products can only be given by a healthcare provider. A learning disorder marked by difficulty reading (dyslexia) . Taking piracetam by mouth improves some reading skills in children with dyslexia. Seizure disorder (epilepsy) . Taking piracetam by mouth reduces some symptoms of epilepsy in some patients who are also taking antiseizure drugs. A movement disorder often caused by antipsychotic drugs (tardive dyskinesia) . Taking piracetam by mouth can reduce some symptoms of tardive dyskinesia. Cocaine use disorder : Piracetam seems to increase cocaine use in people who are addicted to cocaine and are trying to quit. Until more is known, do not use piracetam if you have cocaine use disorder. Epilepsy : Stopping piracetam or decreasing the dose of piracetam might increase the number of seizures in people with epilepsy. If you have epilepsy, only use piracetam under the care of a healthcare provider. Huntington disease : Piracetam seems to increase symptoms in people with Huntington disease. Until more is known, do not use piracetam if you have Huntington disease. Kidney problems : Piracetam is removed from the body by the kidneys. Talk to a healthcare provider before using piracetam if you have kidney problems. Surgery : Piracetam might slow blood clotting. This might result in too much bleeding if it is used before surgery. Stop taking piracetam at least 2 weeks before surgery. Piracetam might slow blood clotting. Taking piracetam along with medications that also slow blood clotting might increase the risk of bruising and bleeding. May BH, Yang AW, Zhang AL, et al. Chinese herbal medicine for mild cognitive impairment and age associated memory impairment: a review of randomised controlled trials. Biogerontology 2009;10(2):109-23. Malykh AG, Sadaie MR. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs 2010;70(3):287-312. Lobaugh NJ, Karaskov V, Rombough V, et al. Piracetam therapy does not enhance cognitive functioning in children with down syndrome. Arch Pediatr Adolesc Med 2001;155(4):442-8. Koskiniemi M, Van Vleymen B, Hakamies L, et al. Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study comparing the efficacy and safety of three dosages of oral piracetam with placebo. J Neurol Neurosurg Psychiatry 1998;64(3):344-8. Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev. 2005;11(2):169-82. Winnicka K, Tomasiak M, Bielawska A. Piracetam--an old drug with novel properties? Acta Pol Pharm. 2005;62(5):405-9. Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neurosci Behav Physiol. 2009;39(3):311-21. Ricci S, Celani MG, Cantisani TA, Righetti E. Piracetam for acute ischaemic stroke. Cochrane Database Syst Rev. 2012 Sep 12;(9):CD000419. Psillas G, Pavlidis P, Karvelis I, et al. Potential efficacy of early treatment of acute acoustic trauma with steroids and piracetam after gunshot noise. Eur Arch Otorhinolaryngol. 2008;265(12):1465-9. Chen SY, Liu JW, Wang YH, et al. The conditions under which piracetam is used and the
Excerpt from a page describing this subject · 34,643 chars · not written by Vinony
Wikidata facts
- Mass
- 142.074
Show 6 more facts
- chemical formula
- C₆H₁₀N₂O₂
- World Health Organisation international non-proprietary name
- piracetam
- MCN code
- 2933.79.10
- canonical SMILES
- C1CC(=O)N(C1)CC(=O)N
- Commons category
- Piracetam
- described at URL
- www.drugs.com/medical-answers/piracetam-3570384
Sources (6)
via Wikidata · CC0
~8 min read
Article
16 sectionsContents
- Efficacy
- Dementia
- Depression and anxiety
- Attention deficit hyperactivity disorder (ADHD)
- Other
- Anti-vasospasm
- Side effects
- Toxicity
- Mechanisms of action
- History
- Society and culture
- Legal status
- Regulatory status
- See also
- References
- External links
Piracetam is a drug that has efficacy in cognitive disorders, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia; sources differ on its usefulness for dementia. Piracetam is sold as a medication in many European countries. Piracetam in the United States is not approved for general use.
Piracetam is in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It is a cyclic derivative of the neurotransmitter GABA and shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid. Related drugs include the anticonvulsants levetiracetam and brivaracetam, and the putative nootropics aniracetam and phenylpiracetam.