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prenalterol
Sign in to saveAlso known as CGP 7760B
Prenalterol, sold under the brand name Hyprenan, is a sympathomimetic agent and cardiac stimulant which acts as a β1-adrenergic receptor partial agonist and is used in the treatment of heart failure. It has selectivity for the β1-adrenergic receptor. Its partial agonist activity or intrinsic sympathomimetic activity is about 60%. It is said to have much greater impact on myocardial contractility than on heart rate. The drug has been marketed in Denmark, Norway, and Sweden.
Chemical data
- Formula
- C12H19NO3
- Molecular weight
- 225.28 g/mol
- IUPAC name
- 4-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenol
- SMILES
- CC(C)NC[C@@H](COC1=CC=C(C=C1)O)O
- InChIKey
- ADUKCCWBEDSMEB-NSHDSACASA-N
- XLogP
- 1.4
- Polar surface area
- 61.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
404 papers- Prenalterol--a new cardioselective inotropic agent.Journal of clinical and hospital pharmacy · 1982
- Electrophysiologic properties of prenalterol.International journal of cardiology · 1983
- The selectivity of xamoterol, prenalterol, and salbutamol as assessed by their effects in the presence and absence of ICI 118,551.Journal of cardiovascular pharmacology · 1988
- Electrophysiological studies with prenalterol.Acta medica Scandinavica. Supplementum · 1982
- Effect of prenalterol in asthmatic patients.European journal of clinical pharmacology · 1982
via PubMed
Wikidata facts
- Mass
- 225.136493
Show 5 more facts
- chemical formula
- C₁₂H₁₉NO₃
- Commons category
- Prenalterol
- canonical SMILES
- CC(C)NCC(COC1=CC=C(C=C1)O)O
- isomeric SMILES
- CC(C)NC[C@@H](COC1=CC=C(C=C1)O)O
- defined daily dose
- 10
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Chemistry
- Synthesis
- Stereospecific
- Racemic
- See also
- References
- Further reading
{{Drugbox | Verifiedfields = changed | verifiedrevid = 464213907 | IUPAC_name = 4-{[(2S)-2-hydroxy-3-(isopropylamino)propyl]oxy}phenol | image = Prenalterol.svg | image_class = skin-invert-image | width = 250px
| tradename = Hyprenan | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral, IV
Excerpted from Wikipedia’s “prenalterol” article, available under the CC BY-SA 4.0 licence.