pyriminil
Sign in to savePyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.
Research
51 papers- Trials of the rodenticide pyriminil against wild house mice (Mus musculus L.).The Journal of hygiene · 1978
- PNU intoxication.American journal of diseases of children (1960) · 1980
- The "sniffing bar".Annals of emergency medicine · 1983
- Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.eLife · 2021
- [Diabetes due to PNU (rat poison)].Harefuah · 1980
via PubMed
Wikidata facts
- Mass
- 272.091
Show 3 more facts
- chemical formula
- C₁₃H₁₂N₄O₃
- canonical SMILES
- C1=CC(=CN=C1)CNC(=O)NC2=CC=C(C=C2)[N+](=O)[O-]
- Commons category
- Pyrinuron
Sources (2)
via Wikidata · CC0
~1 min read
Article
1 sectionsContents
- References
Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.
==References==