RAB18

Also known as RAB18LI1, WARBM3, RAB18, member RAS oncogene family

Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene. It is a member of the Rab family of Ras-related small GTPases.

Gene data

RAB18

Name: RAB18, member RAS oncogene family
Type: protein-coding
Position: 27,504,174–27,545,117 (+)
Aliases: RAB18LI1, WARBM3
Ensembl: ENSG00000099246
RefSeq RNA: NM_001256410.2, NM_001256411.2, NM_001256412.2, NM_001256415.2, NM_021252.5
RefSeq protein: NP_001243339.1, NP_001243340.1, NP_001243341.1, NP_067075.1

The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].

Pathways

Innate Immune System Immune System Membrane Trafficking Metabolism of proteins Vesicle-mediated transport Post-translational protein modification Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic Intra-Golgi and retrograde Golgi-to-ER traffic Golgi-to-ER retrograde transport

via MyGene.info

Gene · Ensembl

RAB18, member RAS oncogene family

Symbol: RAB18
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:27,504,174-27,545,117
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein RAB18 PDB 1x3s.png

Show 5 more facts

HomoloGene ID: 40765
exact match: identifiers.org/ncbigene/22931
genomic end: 27543207
genomic start: 27793197
cytogenetic location: 10p12.1

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Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene. It is a member of the Rab family of Ras-related small GTPases.

Rab18 is a ubiquitously expressed protein with particularly high expression in the brain. Rab18 was first characterised as an endosomal protein in epithelial cells of mouse kidney and intestines. Subsequent studies revealed that Rab18 has a wide intracellular distribution; localising to the Golgi complex, endoplasmic reticulum, lipid droplets, and cytosol of various cell types. In the brain, Rab18 has been isolated in association with synaptic vesicles and has been observed to localise to secretory granules in neuroendocrine cells.