RAD51B
Sign in to saveAlso known as R51H2, RAD51L1, REC2, RAD51 paralog B
DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene.
In the Vinony graph
Vinony's link graph records 12 inbound references to RAD51B, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Vinony links it to 6 Wikipedia language editions.
Gene data
RAD51B- Name
- RAD51 paralog B
- Type
- protein-coding
- Position
- 67,819,741–68,730,218 (+)
- Aliases
- R51H2, RAD51L1, REC2
- Ensembl
- ENSG00000182185
- RefSeq RNA
- NM_001321809.2, NM_001321810.2, NM_001321812.1, NM_001321814.2, NM_001321815.1
- RefSeq protein
- NP_001308738.1, NP_001308739.1, NP_001308741.1, NP_001308743.1, NP_001308744.1
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RAD51 paralog B
- Symbol
- RAD51B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:67,819,741-68,730,218
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 50190
- genetic association
- male breast cancer
- chromosome
- human chromosome 14
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5890
- genomic end
- 69196935
- genomic start
- 68286496
- cytogenetic location
- 14q24.1
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene.
== Function ==
Excerpted from Wikipedia’s “RAD51B” article, available under the CC BY-SA 4.0 licence.