REC8

Also known as HR21spB, REC8L1, Rec8p, REC8 meiotic recombination protein

Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.

Gene data

REC8

Name: REC8 meiotic recombination protein
Type: protein-coding
Aliases: HR21spB, REC8L1, Rec8p

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].

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Gene · Ensembl

REC8 meiotic recombination protein

Symbol: REC8
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:24,171,853-24,180,923
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 3768
exact match: identifiers.org/ncbigene/9985
genomic end: 24649463
genomic start: 24641062
cytogenetic location: 14q12

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Function
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Further reading

Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.

Rec8 is a meiosis-specific component of the cohesin complex that binds sister chromatids in preparation for the two divisions of meiosis. Rec8 is sequentially removed from sister chromatids. It is removed from the arms of chromosomes in the first division - separating homologous chromosomes from each other. However, Rec8 is maintained at centromeres so that sister chromatids are kept joined until anaphase of meiosis II, at which point removal of remaining cohesin leads to the separation of sister chromatids.