RGS11

Also known as RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

Gene data

RGS11

Name: regulator of G protein signaling 11
Type: protein-coding
Position: 268,301–275,980 (−)
Aliases: RS11
Ensembl: ENSG00000076344
RefSeq RNA: NM_001286485.2, NM_001286486.2, NM_003834.3, NM_183337.3, XM_011522719.3
RefSeq protein: NP_001273414.1, NP_001273415.1, NP_003825.1, NP_899180.1, XP_011521021.1

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway intracellular signal transduction

Molecular function

GTPase activity GTPase activity GTPase activator activity GTPase activator activity G-protein beta-subunit binding

Cellular component

cytoplasm plasma membrane plasma membrane protein-containing complex neuron projection

Pathways

Signal Transduction Signal Transduction Signaling by GPCR Signaling by GPCR GPCR downstream signalling GPCR downstream signalling Chaperonin-mediated protein folding Protein folding Metabolism of proteins G alpha (i) signalling events

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 11

Symbol: RGS11
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:268,301-275,980
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

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Contents

References
Further reading

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

Excerpted from Wikipedia’s “RGS11” article, available under the CC BY-SA 4.0 licence.