RGS20

Also known as RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Gene data

RGS20

Name: regulator of G protein signaling 20
Type: protein-coding
Position: 53,851,795–53,959,303 (+)
Aliases: RGSZ1, ZGAP1, g(z)GAP, gz-GAP
Ensembl: ENSG00000147509
RefSeq RNA: NM_001286673.2, NM_001286674.2, NM_001286675.2, NM_003702.5, NM_170587.4
RefSeq protein: NP_001273602.1, NP_001273603.1, NP_001273604.1, NP_003693.2, NP_733466.1

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway

Molecular function

GTPase activity GTPase activity GTPase activator activity GTPase activator activity protein binding

Cellular component

nucleus cytoplasm cytoplasm trans-Golgi network plasma membrane cytoplasmic side of plasma membrane membrane

Pathways

Signal Transduction Signal Transduction Signaling by GPCR Signaling by GPCR GPCR downstream signalling GPCR downstream signalling G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 20

Symbol: RGS20
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:53,851,795-53,959,303
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]

Excerpted from Wikipedia’s “RGS20” article, available under the CC BY-SA 4.0 licence.