Structure via PubChem · Public domain (PubChem)
ribociclib
Sign in to saveAlso known as LEE011, LEE-011
Ribociclib, sold under the brand name Kisqali, is a medication used for the treatment of certain kinds of breast cancer. Ribociclib is a kinase inhibitor. It was developed by Novartis and Astex Pharmaceuticals.
In the Vinony graph
Vinony's link graph records 492 inbound references to ribociclib, and connects out to drug metabolism, tiazofurin and nitrogen.
It sits within the topics 1-Piperazinyl compounds, Carboxamides and CDK inhibitors.
Vinony links it to 14 Wikipedia language editions.
Key facts
- Drug.image
- Ribociclib skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Ribociclib-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Kisqali
- Drug.MedlinePlus
- a617008
- Drug.DailyMedID
- Ribociclib
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antineoplastic, CDK inhibitor
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EF02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- Unknown
- Drug.protein_bound
- ~70%
- Drug.metabolism
- Liver (CYP3A4)
via Wikipedia infobox
Chemical data
- Formula
- C23H30N8O
- Molecular weight
- 434.5 g/mol
- IUPAC name
- 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
- SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- InChIKey
- RHXHGRAEPCAFML-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 91.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- oral
- Indications
- lymphoma, melanoma, glioblastoma multiforme, liposarcoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.254
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₃H₃₀N₈O
- canonical SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- NCI Thesaurus ID
- C95701
- World Health Organisation international non-proprietary name
- ribociclib
- Commons category
- Ribociclib
- subject has role
- protein kinase inhibitors
- medical condition treated
- breast cancer
Sources (5)
via Wikidata · CC0
~10 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- References
{{Infobox drug | image = Ribociclib skeletal.svg | image_class = skin-invert-image | alt = | caption = | image2 = Ribociclib-from-xtal-3D-bs-17.png | image_class2 = bg-transparent
| pronounce = | tradename = Kisqali | Drugs.com = | MedlinePlus = a617008 | DailyMedID = Ribociclib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Antineoplastic, CDK inhibitor | ATC_prefix = L01 | ATC_suffix = EF02
Excerpted from Wikipedia’s “ribociclib” article, available under the CC BY-SA 4.0 licence.