Structure via PubChem · Public domain (PubChem)
In the Vinony graph
Vinony's link graph records 492 inbound references to رایبوسیکلیب, and connects out to drug metabolism, tiazofurin and nitrogen.
It is catalogued under topics including 1-Piperazinyl compounds, Carboxamides and CDK inhibitors.
Vinony links it to 14 Wikipedia language editions.
Key facts
- Drug.image
- Ribociclib skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Ribociclib-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Kisqali
- Drug.MedlinePlus
- a617008
- Drug.DailyMedID
- Ribociclib
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antineoplastic, CDK inhibitor
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EF02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- Unknown
- Drug.protein_bound
- ~70%
- Drug.metabolism
- Liver (CYP3A4)
via Wikipedia infobox
Chemical data
- Formula
- C23H30N8O
- Molecular weight
- 434.5 g/mol
- IUPAC name
- 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
- SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- InChIKey
- RHXHGRAEPCAFML-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 91.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- oral
- Indications
- lymphoma, melanoma, glioblastoma multiforme, liposarcoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.254
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₃H₃₀N₈O
- canonical SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- NCI Thesaurus ID
- C95701
- World Health Organisation international non-proprietary name
- ribociclib
- Commons category
- Ribociclib
- subject has role
- protein kinase inhibitors
- medical condition treated
- breast cancer
Sources (5)
via Wikidata · CC0
Connections
drug metabolism
Entity
tiazofurin
Entity
nitrogen
Entity
medication
Entity
The Guardian
Entity
anemia
Entity
public domain
Entity
digital object identifier
Entity
breast cancer
Entity
chemical formula
Entity
Citrus × paradisi
Entity
chemotherapy
Entity
blood plasma
Entity
Hypericum perforatum
Entity
molar mass
Entity
nausea
Entity
placebo
Entity
PubMed
Entity
DNA replication
Entity
excretion
Entity
Categories
1-Piperazinyl compoundsCarboxamidesCDK inhibitorsChemicals using indexlabelsCyclopentyl compoundsCYP3A4 inhibitorsDisubstituted pyridinesDrugs developed by NovartisDrugs with non-standard legal statusECHA InfoCard ID from WikidataMultiple chemicals in Infobox drugProtein kinase inhibitorsPyrimidinesSource attribution