Structure via PubChem · Public domain (PubChem)
In the Vinony graph
Vinony's link graph records 492 inbound references to Ribociclib, and connects out to drug metabolism, tiazofurin and nitrogen.
It sits within the topics 1-Piperazinyl compounds, Carboxamides and CDK inhibitors.
Vinony links it to 14 Wikipedia language editions.
Key facts
- Drug.image
- Ribociclib skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Ribociclib-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Kisqali
- Drug.MedlinePlus
- a617008
- Drug.DailyMedID
- Ribociclib
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antineoplastic, CDK inhibitor
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EF02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- Unknown
- Drug.protein_bound
- ~70%
- Drug.metabolism
- Liver (CYP3A4)
via Wikipedia infobox
Chemical data
- Formula
- C23H30N8O
- Molecular weight
- 434.5 g/mol
- IUPAC name
- 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
- SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- InChIKey
- RHXHGRAEPCAFML-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 91.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- oral
- Indications
- lymphoma, melanoma, glioblastoma multiforme, liposarcoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.254
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₃H₃₀N₈O
- canonical SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- NCI Thesaurus ID
- C95701
- World Health Organisation international non-proprietary name
- ribociclib
- Commons category
- Ribociclib
- subject has role
- protein kinase inhibitors
- medical condition treated
- breast cancer
Sources (5)
via Wikidata · CC0
Connections
drug metabolism
Entity
tiazofurin
Entity
nitrogen
Entity
medication
Entity
The Guardian
Entity
anemia
Entity
public domain
Entity
digital object identifier
Entity
breast cancer
Entity
chemical formula
Entity
Citrus × paradisi
Entity
chemotherapy
Entity
blood plasma
Entity
Hypericum perforatum
Entity
molar mass
Entity
nausea
Entity
placebo
Entity
PubMed
Entity
DNA replication
Entity
excretion
Entity
Categories
1-Piperazinyl compoundsCarboxamidesCDK inhibitorsChemicals using indexlabelsCyclopentyl compoundsCYP3A4 inhibitorsDisubstituted pyridinesDrugs developed by NovartisDrugs with non-standard legal statusECHA InfoCard ID from WikidataMultiple chemicals in Infobox drugProtein kinase inhibitorsPyrimidinesSource attribution