ropinirol

Also known as Requip®, SK&F-101468-A, SK&F-101468A, Ropinirole, Ropinirolum

Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). It is taken by mouth.

Chemical data

Formula: C16H24N2O
Molecular weight: 260.37 g/mol
IUPAC name: 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
SMILES: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
InChIKey: UHSKFQJFRQCDBE-UHFFFAOYSA-N
XLogP: 2.7
Polar surface area: 32.3 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Research

1,116 papers

Ropinirole.2006
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.Cell stem cell · 2023
[Ropinirol: a new dopamine agonist in the treatment of Parkinson's disease].Neurologia (Barcelona, Spain) · 1997
[Systemic review and meta-analysis of tolerability and safety between different titration regimes of ropinirol dose in the treatment of Parkinson's disease].Neurologia (Barcelona, Spain) · 2007
Dopamine agonists.The Medical clinics of North America · 1999

via PubMed

~6 min read

Encyclopedic overview

11 sections

Contents

Medical uses
Side effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
History
Society and culture
Lawsuit
See also
References

Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). It is taken by mouth.

Common side effects include sleepiness, vomiting, and dizziness. Serious side effects may include pathological gambling, hypersexuality, low blood pressure with standing and hallucinations. Use in pregnancy and breastfeeding is of unclear safety. It is a dopamine agonist and works by triggering dopamine D2 receptors.

Excerpted from Wikipedia’s “ropinirol” article, available under the CC BY-SA 4.0 licence.