SCGN

Also known as CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein

Secretagogin is a protein that in humans is encoded by the SCGN gene.

Gene data

SCGN

Name: secretagogin, EF-hand calcium binding protein
Type: protein-coding
Position: 25,652,201–25,701,783 (+)
Aliases: CALBL, DJ501N12.8, SECRET, SEGN, setagin
Ensembl: ENSG00000079689
RefSeq RNA: NM_006998.4, XM_054354044.1
RefSeq protein: NP_008929.2, XP_054210019.1

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008].

Gene Ontology

Molecular function

calcium ion binding calcium ion binding calcium ion binding

Article

4 sections

Contents

Expression
Function
References
Further reading

Secretagogin is a protein that in humans is encoded by the SCGN gene.

== Expression == Secretagogin is expressed in a variety of organs and tissues. It is expressed in pancreatic β cells, where it participates in insulin release. In the brain, it is expressed in interneurons and pyramidal cells of the hippocampus. In the brainstem, it is expressed neurons of the superior colliculus, cuneiform nucleus, locus coeruleus, and solitary tract nucleus. In the spinal cord, secretagogin is expressed in the dorsal horn and dorsal root ganglia (up to 7% of DRGs) where it is co-expressed with calcitonin gene-related peptide (CGRP). Secretagogin is also expressed in the sciatic nerve. In gut tissue, secretagogin is expressed in 10% of enteric neurons of the small intestine, while it is expressed in 5% of enteric neurons of the proximal colon, and 25% in the distal colon. Single-cell RNA sequencing of human and mouse intestinal tissue suggests that secretagogin is also expressed in about 15% of enteroendocrine cells.