SCNN1D
Sign in to saveAlso known as ENaCd, ENaCdelta, SCNED, dNaCh, sodium channel epithelial 1 delta subunit, sodium channel epithelial 1 subunit delta
The SCNN1D gene encodes for the δ (delta) subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1G.
In the Vinony graph
Within Vinony's link graph, SCNN1D is referenced by 300 other articles, and connects out to Wikidata, PubMed and Ensembl genome database project.
It sits within the topics Genes on human chromosome 1 and Sodium channels.
Its subject is documented across 5 Wikipedia language editions.
Gene data
SCNN1D- Name
- sodium channel epithelial 1 subunit delta
- Type
- protein-coding
- Position
- 1,280,436–1,292,029 (+)
- Aliases
- ENaCd, ENaCdelta, SCNED, dNaCh
- Ensembl
- ENSG00000162572
- RefSeq RNA
- NM_001130413.4, NM_002978.2, NR_037668.3
- RefSeq protein
- NP_001123885.2
Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sodium channel epithelial 1 subunit delta
- Symbol
- SCNN1D
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:1,280,436-1,292,029
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 48152
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6339
- genomic end
- 1227409
- genomic start
- 1215816
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.33
- expressed in
- cingulate gyrus
Sources (3)
via Wikidata · CC0
~5 min read
Encyclopedic overview
9 sectionsContents
- History
- Gene structure
- Tissue-specific expression
- Protein structure
- Associated diseases
- Notes
- References
- Further reading
- External links
The SCNN1D gene encodes for the δ (delta) subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1G.
ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1D) represents that these are NON-voltage-gated channels.
Excerpted from Wikipedia’s “SCNN1D” article, available under the CC BY-SA 4.0 licence.