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GeneQ18053184· pop 6· linked from 5 articles

SPRED2

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Also known as Spred-2, sprouty related EVH1 domain containing 2, NS14

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

In the Vinony graph

Within Vinony's link graph, SPRED2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It sits within the topics EVH1 domain, Genes on human chromosome 2 and Human proteins.

Its subject is documented across 6 Wikipedia language editions.

Gene data

SPRED2

Name: sprouty related EVH1 domain containing 2
Type: protein-coding
Position: 65,310,851–65,432,682 (−)
Aliases: NS14, Spred-2
Ensembl: ENSG00000198369
RefSeq RNA: NM_001128210.2, NM_181784.3, XM_005264200.6, XM_005264202.6, XM_017003576.2
RefSeq protein: NP_001121682.1, NP_861449.2, XP_005264257.2, XP_005264259.1, XP_016859065.1

SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

regulation of signal transduction negative regulation of epithelial to mesenchymal transition negative regulation of epithelial to mesenchymal transition negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of MAPK cascade positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of DNA damage response, signal transduction by p53 class mediator

Molecular function

stem cell factor receptor binding stem cell factor receptor binding protein binding protein kinase binding protein kinase binding protein kinase binding protein serine/threonine kinase inhibitor activity protein serine/threonine kinase inhibitor activity

Cellular component

cytoplasm cytoplasm cytosol cytosol plasma membrane plasma membrane plasma membrane membrane

Pathways

Signal Transduction Disease Signaling by FGFR Signaling by FGFR1 Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling Diseases of signal transduction by growth factor receptors and second messengers RAF/MAP kinase cascade MAPK family signaling cascades MAPK1/MAPK3 signaling

via MyGene.info

Gene · Ensembl

sprouty related EVH1 domain containing 2

Symbol: SPRED2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:65,310,851-65,432,682
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein SPRED2 PDB 2jp2.png

Show 9 more facts

HomoloGene ID: 24918
genetic association: celiac disease
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/200734
genomic end: 65659771
genomic start: 65537985
chromosome: human chromosome 2
cytogenetic location: 2p14
expressed in: Brodmann area 46

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

== Function ==

Excerpted from Wikipedia’s “SPRED2” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

EVH1 domain Genes on human chromosome 2 Human proteins SPR domain