STC2
Sign in to saveAlso known as STC-2, STCRP, stanniocalcin 2
Stanniocalcin-2 is a protein that in humans is encoded by the STC2 gene.
Gene data
STC2- Name
- stanniocalcin 2
- Type
- protein-coding
- Position
- 173,314,723–173,328,447 (−)
- Aliases
- STC-2, STCRP
- Ensembl
- ENSG00000113739
- RefSeq RNA
- NM_003714.3
- RefSeq protein
- NP_003705.1
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
stanniocalcin 2
- Symbol
- STC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:173,314,708-173,328,447
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2753
- exact match
- identifiers.org/ncbigene/8614
- genomic end
- 173328447
- genomic start
- 173314723
- cytogenetic location
- 5q35.2
Sources (3)
via Wikidata · CC0
~2 min read
Article
2 sectionsContents
- References
- Further reading
Stanniocalcin-2 is a protein that in humans is encoded by the STC2 gene.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues.