STIP1

Name

stress induced phosphoprotein 1

Type

protein-coding

Aliases

HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009].

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Gene · Ensembl

stress induced phosphoprotein 1

Symbol

STIP1

Biotype

Protein coding

Organism

Homo sapiens

Location

11:64,185,272-64,204,549

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein STIP1 PDB 1elr.png

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