sulbactam
Also known as (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide, penicillanic acid 1,1-dioxide, penicillanic acid sulfone, Sulbactam Benzathine, (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.
Chemical data
- Formula
- C8H11NO5S
- Molecular weight
- 233.24 g/mol
- IUPAC name
- (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- SMILES
- CC1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)C
- InChIKey
- FKENQMMABCRJMK-RITPCOANSA-N
- XLogP
- -1
- Polar surface area
- 100 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
5,301 papers~1 min read
Article
4 sectionsContents
- Medical uses
- Mechanism
- References
- Further reading
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.
It was patented in 1977 and approved for medical use in 1986.