temsirolimus
Sign in to saveAlso known as CCI-779, Torisel®, 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin, CCI 779
Temsirolimus, sold under the brand name Torisel, is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the U.S. Food and Drug Administration (FDA) in May 2007, and was also approved by the European Medicines Agency (EMA) in November 2007. It is a derivative and prodrug of sirolimus.
Wikidata facts
- Has part
- carbon
- Mass
- 1029.602486
- Has use
- medication
Show 8 more facts
- chemical formula
- C₅₆H₈₇NO₁₆
- isomeric SMILES
- C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC
- canonical SMILES
- CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
- significant drug interaction
- fluconazole
- subject has role
- protein kinase inhibitors
- medical condition treated
- mantle cell lymphoma
- physically interacts with
- mechanistic target of rapamycin kinase
- Commons category
- Temsirolimus
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~6 min read
Encyclopedic overview
8 sectionsContents
- Mechanism of action
- Efficacy
- Adverse reactions
- Toxicity to lungs
- Dosing
- See also
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 409344559 | IUPAC_name = (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate | image = Temsirolimus.svg | image_class = skin-invert-image
| tradename = Torisel | Drugs.com = | MedlinePlus = a607071 | licence_EU = yes | DailyMedID = Temsirolimus | licence_US = Torisel | pregnancy_AU = D | pregnancy_US = N | pregnancy_category = | legal_AU = S4 | legal_CA = Rx-only | legal_UK = POM | legal_US = Rx-only | legal_EU = Rx-only | legal_EU_comment = | legal_status = | routes_of_administration = Intravenous | ATC_prefix = L01 | ATC_suffix = EG01
Excerpted from Wikipedia’s “temsirolimus” article, available under the CC BY-SA 4.0 licence.
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