TGFBI

Also known as BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.

Gene data

TGFBI

Name: transforming growth factor beta induced
Type: protein-coding
Position: 136,028,988–136,063,818 (+)
Aliases: BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
Ensembl: ENSG00000120708
RefSeq RNA: NM_000358.3
RefSeq protein: NP_000349.1

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

angiogenesis

Article

4 sections

Contents

Function
Clinical significance
References
Further reading

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.

== Function ==