TIAL1

Also known as TCBP, TIAR, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule associated RNA binding protein like 1

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.

Gene data

TIAL1

Name: TIA1 cytotoxic granule associated RNA binding protein like 1
Type: protein-coding
Position: 119,571,802–119,597,029 (−)
Aliases: TCBP, TIAR
Ensembl: ENSG00000151923
RefSeq RNA: NM_001033925.2, NM_001323964.2, NM_001323965.2, NM_001323967.2, NM_001323968.2
RefSeq protein: NP_001029097.1, NP_001310893.1, NP_001310894.1, NP_001310896.1, NP_001310897.1

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of alternative mRNA splicing, via spliceosome

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Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been shown to function differently with respect to post-transcriptional silencing.