ticagrelor

Also known as AR-C126532XX, AZD6140, Brilinta®, Brilique®, AZD 6140, AZD-6140, (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-D)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. The drug is produced by AstraZeneca. thumb|90 mg tablet of Brilinta

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 443228756
Drug.image: Ticagrelor.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.image2: Ticagrelor ball-and-stick animation.gif
Drug.tradename: Brilinta, Brilique, others
Drug.MedlinePlus: a611050
Drug.DailyMedID: Ticagrelor
Drug.pregnancy_AU: B1
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: B01
Drug.ATC_suffix: AC24
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only

via Wikipedia infobox

Chemical data

Formula: C23H28F2N6O4S
Molecular weight: 522.6 g/mol
IUPAC name: (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
SMILES: CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
InChIKey: OEKWJQXRCDYSHL-FNOIDJSQSA-N
XLogP: 2
Polar surface area: 164 Å²
H-bond donors: 4
H-bond acceptors: 12
Formal charge: 0

via PubChem

Research

5,022 papers

Ticagrelor.Profiles of drug substances, excipients, and related methodology · 2022
Ticagrelor: clinical development and future potential.Reviews in cardiovascular medicine · 2021
Ticagrelor: a cardiometabolic drug targeting erythrocyte-mediated purinergic signaling?American journal of physiology. Heart and circulatory physiology · 2021
Ticagrelor-Associated Urticaria.American journal of therapeutics · 2023
Is ticagrelor worth its high cost and side-effects?Acta cardiologica · 2019

via PubMed

Wikidata facts

Mass: 522.186

Show 6 more facts

chemical formula: C₂₃H₂₈F₂N₆O₄S
World Health Organisation international non-proprietary name: ticagrelor
canonical SMILES: CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO
isomeric SMILES: CCCSC1=NC2=C(C(=N1)N[C@@H]3C[C@H]3C4=CC(=C(C=C4)F)F)N=NN2[C@@H]5C[C@@H]([C@H]([C@H]5O)O)OCCO
Commons category: Ticagrelor
defined daily dose: 0.18

Sources (6)

via Wikidata · CC0

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