timiperone
Sign in to saveTimiperone, sold under the brand name Tolopelon, is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia. It is similar in chemical structure to benperidol, but has a thiourea group instead of a urea group. It acts as an antagonist for the D2 and 5-HT2A receptors.
Research
32 papers- Carbonyl reduction of timiperone in human liver cytosol.Pharmacology & toxicology · 1998
- Effect of timiperone on 3H-spiroperidol binding to rat striatal dopamine receptors.European journal of pharmacology · 1979
- Effect of hyperprolactinemia induced by neuroleptic agent, timiperone, on porphyrin content of mouse harderian gland.The Journal of toxicological sciences · 1997
- Targeting Sirtuin 1 for therapeutic potential: Drug repurposing approach integrating docking and molecular dynamics simulations.PloS one · 2023
- Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties.Arzneimittel-Forschung · 1981
via PubMed
Wikidata facts
- Mass
- 397.162
Show 3 more facts
- chemical formula
- C₂₂H₂₄FN₃OS
- canonical SMILES
- C1CN(CCC1N2C3=CC=CC=C3NC2=S)CCCC(=O)C4=CC=C(C=C4)F
- Commons category
- Timiperone
Sources (2)
via Wikidata · CC0
~1 min read
Article
1 sectionsContents
- References
Timiperone, sold under the brand name Tolopelon, is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia. It is similar in chemical structure to benperidol, but has a thiourea group instead of a urea group. It acts as an antagonist for the D2 and 5-HT2A receptors.
== References ==
Available in 8 languages
via Wikidata sitelinks · CC0
Connections
fluphenazine
Entity
zuclopenthixol
Entity
pipotiazine
Entity
perphenazine
Entity
flupentixol
Entity
clopenthixol
Entity
Japan
Country
medication
Entity
International Standard Book Number
Entity
nervous system
Entity
schizophrenia
Entity
digital object identifier
Entity
chemical formula
Entity
urea
Entity
functional group
Entity
molar mass
Entity
Q180686
Entity
CAS Registry Number
Entity
antipsychotics
Entity
PubChem
Entity
Categories
4-Fluorophenyl compoundsButyrophenone antipsychoticsChemical pages without DrugBank identifierDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs not assigned an ATC codeDrugs with non-standard legal statusECHA InfoCard ID from WikidataPiperidinylbenzimidazolinesThioureasTypical antipsychotics