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tolperisone
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Tolperisone (trade name Mydocalm among others) is a centrally acting skeletal muscle relaxant used for the treatment of increased muscle tone associated with neurological diseases. It has been used since the 1960s.
In the Vinony graph
Within Vinony's link graph, tolperisone is referenced by 388 other articles, and connects out to neuromuscular-blocking drug, valproic acid and voltage-gated calcium channel complex.
It is catalogued under topics including 1-Piperidinyl compounds, Aromatic ketones and Calcium channel blockers.
Its subject is documented across 11 Wikipedia language editions.
Chemical data
- Formula
- C16H23NO
- Molecular weight
- 245.36 g/mol
- IUPAC name
- 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one
- SMILES
- CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
- InChIKey
- FSKFPVLPFLJRQB-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 20.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Myalgia, Arthralgia, Spasticity, Low back pain
via ChEMBL · EBI
Research
218 papers- Tolperisone induces UPR-mediated tumor inhibition and synergizes with proteasome inhibitor and immunotherapy by targeting LSD1.Expert opinion on therapeutic targets · 2023
- Pregabalin-Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats.Pharmaceuticals (Basel, Switzerland) · 2023
- Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects.CNS neuroscience & therapeutics · 2008
- Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone.Archives of pharmacal research · 2023
- Tolperisone for the Treatment of Acute Muscle Spasm of the Back: Results from the Dose-Ranging Phase 2 STAR Study (NCT03802565).Journal of pain research · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 245.178
- Has use
- drug
Show 4 more facts
- chemical formula
- C₁₆H₂₃NO
- canonical SMILES
- CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
- Commons category
- Tolperisone
- defined daily dose
- 0.2
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Contraindications and cautions
- Side effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Society and culture
- Brand names
- See also
- References
Tolperisone (trade name Mydocalm among others) is a centrally acting skeletal muscle relaxant used for the treatment of increased muscle tone associated with neurological diseases. It has been used since the 1960s.
== Medical uses == Tolperisone is indicated for use in the treatment of pathologically increased tone of the skeletal muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.
Excerpted from Wikipedia’s “tolperisone” article, available under the CC BY-SA 4.0 licence.