Structure via PubChem · Public domain (PubChem)
trihexyphenidyl
Sign in to saveAlso known as Artane®, benzhexol, Trihexyphénidyle, Trihexyphenidylum, Benzhexol Hydrochloride, (RS)-1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol, Apo-trihex, Trihexifenidilo
Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease. It was approved by the FDA for the treatment of Parkinson's in the US in 1949.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 470614772
- Drug.IUPAC_name
- (RS)-1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol
- Drug.image
- Trihexyphenidyl.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Trihexyphenidyl 3D.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Artane, Parkin, Pacitane, Hexymer
- Drug.MedlinePlus
- a682160
- Drug.DailyMedID
- Trihexyphenidyl
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- Oral
- Drug.ATC_prefix
- N04
- Drug.ATC_suffix
- AA01
- Drug.legal_AU
- S8
- Drug.legal_BR
- B1
- Drug.legal_US
- Rx-Only
- Drug.elimination_half life
- 3.3-4.1 hours
via Wikipedia infobox
Chemical data
- Formula
- C20H31NO
- Molecular weight
- 301.5 g/mol
- IUPAC name
- 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
- SMILES
- C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
- InChIKey
- HWHLPVGTWGOCJO-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
1,362 papers- Trihexyphenidyl dependence.Acta psychiatrica Scandinavica · 1984
- Trihexyphenidyl withdrawal encephalopathy.Annals of neurology · 1997
- Trihexyphenidyl and torticollis.Neurology · 1986
- Trihexyphenidyl abuse.The American journal of psychiatry · 1977
- Withdrawal of trihexyphenidyl.Acta psychiatrica Scandinavica · 1985
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 301.241
- Has use
- medication
Show 6 more facts
- Commons category
- Trihexyphenidyl
- chemical formula
- C₂₀H₃₁NO
- significant drug interaction
- (±)-promethazine
- canonical SMILES
- C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
- defined daily dose
- 10
- subject has role
- muscarinic antagonist
Sources (8)
via Wikidata · CC0
~8 min read
Encyclopedic overview
14 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Stereochemistry
- History
- Society and culture
- Recreational use
- References
Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease. It was approved by the FDA for the treatment of Parkinson's in the US in 1949.
Trihexyphenidyl is a therapeutic alternative on the World Health Organization's List of Essential Medicines.
Excerpted from Wikipedia’s “trihexyphenidyl” article, available under the CC BY-SA 4.0 licence.