troleandomycin

Also known as TAO, Triacetyloleandomycin, Tribiocillina, Oleandocetine, Oleandomycin triacetyl ester, Oleandomycin triacetate

Troleandomycin (TAO for short) is a macrolide antibiotic. It was sold in Italy (branded Triocetin) and Turkey (branded Tekmisin). It is no longer sold in Italy as of 2018.

Research

887 papers

Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma.The Cochrane database of systematic reviews · 2001
Hepatotoxicity of erythromycin.The Journal of infectious diseases · 1969
Liquid chromatography of troleandomycin.Journal of chromatography. A · 2001
Troleandomycin in the treatment of difficult asthma.The Journal of allergy and clinical immunology · 1993
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.The Journal of pharmacology and experimental therapeutics · 1983

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Wikidata facts

Mass: 813.451

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chemical formula: C₄₁H₆₇NO₁₅
canonical SMILES: CC1CC(C(C(O1)OC2C(CC3(CO3)C(=O)C(C(C(C(OC(=O)C(C(C2C)OC4CC(C(C(O4)C)OC(=O)C)OC)C)C)C)OC(=O)C)C)C)OC(=O)C)N(C)C
isomeric SMILES: C[C@@H]1C[C@@H]([C@H]([C@@H](O1)O[C@H]2[C@H](C[C@@]3(CO3)C(=O)[C@@H]([C@H]([C@H]([C@H](OC(=O)[C@@H]([C@H]([C@@H]2C)O[C@H]4C[C@@H]([C@H]([C@@H](O4)C)OC(=O)C)OC)C)C)C)OC(=O)C)C)C)OC(=O)C)N(C)C
World Health Organisation international non-proprietary name: troleandomycin
defined daily dose: 1

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References

{{Drugbox | Verifiedfields = changed | verifiedrevid = 470617807 | IUPAC_name = (3R,5R,6R,7S,8R,11R,12S,13R,14S,15S)-12-[(4-O-acetyl-2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-{[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadec-6-yl acetate | image = troleandomycin.png | image_class = skin-invert-image