Structure via PubChem · Public domain (PubChem)
vaborbactam
Sign in to saveVaborbactam (INN) is a non-β-lactam β-lactamase inhibitor discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the β-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial infections.
In the Vinony graph
Within Vinony's link graph, vaborbactam is referenced by 186 other articles, and connects out to ceftolozane/tazobactam, World Health Organization and zinc.
It sits within the topics Antibiotics, Beta-lactamase inhibitors and Boronate esters.
Its subject is documented across 7 Wikipedia language editions.
Chemical data
- Formula
- C12H16BNO5S
- Molecular weight
- 297.14 g/mol
- IUPAC name
- 2-[(3R,6S)-2-hydroxy-3-[(2-thiophen-2-ylacetyl)amino]oxaborinan-6-yl]acetic acid
- SMILES
- B1([C@H](CC[C@H](O1)CC(=O)O)NC(=O)CC2=CC=CS2)O
- InChIKey
- IOOWNWLVCOUUEX-WPRPVWTQSA-N
- Polar surface area
- 124 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- parenteral
- Indications
- urinary tract infection, bacterial disease, Renal insufficiency
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 297.084
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₂H₁₆BNO₅S
- canonical SMILES
- B1(C(CCC(O1)CC(=O)O)NC(=O)CC2=CC=CS2)O
- isomeric SMILES
- B1([C@H](CC[C@H](O1)CC(=O)O)NC(=O)CC2=CC=CS2)O
- medical condition treated
- urinary tract infection
- Commons category
- Vaborbactam
via Wikidata · CC0
~5 min read
Encyclopedic overview
2 sectionsContents
- Biochemistry
- References
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Excerpted from Wikipedia’s “vaborbactam” article, available under the CC BY-SA 4.0 licence.