VAMP2

Also known as SYB2, VAMP-2, vesicle associated membrane protein 2, NEDHAHM

thumb|Hypothetic models of VAMP2 conformations and engagement in SNARE complex assembly for neurotransmitter release

Gene data

VAMP2

Name: vesicle associated membrane protein 2
Type: protein-coding
Aliases: NEDHAHM, SYB2, VAMP-2

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008].

via MyGene.info