Structure via PubChem · Public domain (PubChem)
vesnarinone
Sign in to saveVesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.
Chemical data
- Formula
- C22H25N3O4
- Molecular weight
- 395.5 g/mol
- IUPAC name
- 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
- SMILES
- COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC
- InChIKey
- ZVNYJIZDIRKMBF-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 71.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- HIV infection
via ChEMBL · EBI
Research
254 papers- Vesnarinone: a differentiation-inducing anti-cancer drug.Anti-cancer drugs · 2003
- Clinical characteristics of vesnarinone.Drug safety · 2004
- Precautions for use and adverse effects of vesnarinone: potential mechanisms and future therapies.Drug safety · 2004
- Vesnarinone: a potential cytokine inhibitor.Journal of cardiac failure · 1996
- Vesnarinone-induced granulocytopenia: incidence in Japan and recommendations for safety.Journal of clinical pharmacology · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 395.185
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₂H₂₅N₃O₄
- canonical SMILES
- COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC
- subject has role
- phosphodiesterase inhibitor
- Commons category
- Vesnarinone
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Vesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.
== References ==
Excerpted from Wikipedia’s “vesnarinone” article, available under the CC BY-SA 4.0 licence.