vesnarinone
Sign in to saveVesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.
Research
254 papers- Vesnarinone: a differentiation-inducing anti-cancer drug.Anti-cancer drugs · 2003
- Clinical characteristics of vesnarinone.Drug safety · 2004
- Precautions for use and adverse effects of vesnarinone: potential mechanisms and future therapies.Drug safety · 2004
- Vesnarinone: a potential cytokine inhibitor.Journal of cardiac failure · 1996
- Vesnarinone-induced granulocytopenia: incidence in Japan and recommendations for safety.Journal of clinical pharmacology · 1996
via PubMed
Wikidata facts
- Mass
- 395.185
Show 3 more facts
- chemical formula
- C₂₂H₂₅N₃O₄
- canonical SMILES
- COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC
- Commons category
- Vesnarinone
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Vesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.
== References ==
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Categories
2-QuinolonesBenzylpiperazinesCatechol ethersChemical pages without DrugBank identifierDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs not assigned an ATC codeDrugs with non-standard legal statusInotropic agentsN-benzoylpiperazinesPDE3 inhibitorsPhenylpiperazines