Structure via PubChem · Public domain (PubChem)
vibegron
Sign in to saveAlso known as Gemtesa
Vibegron, sold under the brand name Gemtesa, is a medication for the treatment of overactive bladder. Vibegron is a selective beta-3 adrenergic receptor agonist.
Chemical data
- Formula
- C26H28N4O3
- Molecular weight
- 444.5 g/mol
- IUPAC name
- (6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carboxamide
- SMILES
- C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)[C@@H]3CCC4=NC=CC(=O)N34)[C@@H](C5=CC=CC=C5)O
- InChIKey
- DJXRIQMCROIRCZ-XOEOCAAJSA-N
- XLogP
- 1.8
- Polar surface area
- 94 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Admin. routes
- oral
- Indications
- overactive bladder, hypertension, irritable bowel syndrome, Urinary incontinence
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 444.216
Show 3 more facts
- canonical SMILES
- C1CC(NC1CC2=CC=C(C=C2)NC(=O)C3CCC4=NC=CC(=O)N34)C(C5=CC=CC=C5)O
- chemical formula
- C₂₆H₂₈N₄O₃
- isomeric SMILES
- C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)[C@@H]3CCC4=NC=CC(=O)N34)[C@@H](C5=CC=CC=C5)O
Sources (2)
via Wikidata · CC0
~8 min read
Encyclopedic overview
15 sectionsContents
- Efficacy
- Medical uses
- Safety
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- History
- Society and culture
- Legal status
- Names
- Veterinary uses
- References
- External links
Vibegron, sold under the brand name Gemtesa, is a medication for the treatment of overactive bladder. Vibegron is a selective beta-3 adrenergic receptor agonist.
The most common side effects include headache, urinary tract infection, common cold, diarrhea, nausea, and upper respiratory tract infection.
Excerpted from Wikipedia’s “vibegron” article, available under the CC BY-SA 4.0 licence.