vimentin
Sign in to saveAlso known as epididymis secretory sperm binding protein, uniprot:P08670, epididymis luminal protein 113, VIM
thumb|328px|Immunofluorescence staining pattern of vimentin antibodies. Produced by incubating vimentin primary antibodies and FITC labelled secondary antibodies with HEp-20-10 cells.
Protein · UniProt
Vimentin
- Gene
- VIM
- Organism
- Homo sapiens (Human)
- Length
- 466 aa
- Molecular mass
- 53,652 Da
- Evidence
- 1: Evidence at protein level
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-med…
Swiss-Prot (reviewed) · via UniProt
Research
37,030 papers- Vimentin in cancer and its potential as a molecular target for cancer therapy.Cellular and molecular life sciences : CMLS · 2011
- Vimentin: Regulation and pathogenesis.Biochimie · 2022
- Spatial single-cell protein landscape reveals vimentin(high) macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma.Nature cancer · 2024
- Vimentin cage - A double-edged sword in host anti-infection defense.Current opinion in cell biology · 2024
- Vimentin at the core of wound healing.Trends in cell biology · 2024
via PubMed
Clinical Trials
10 registered- UNKNOWNDiagnostic Value of Anti-MCV in Pts With RAAssiut University · NCT03265236
- COMPLETEDA Study on the Prevalence of the Modified Citrullinated Vimentin Anti-body (Anti-MCV) in an Irish Rheumatoid Arthritis (RA) Population and to Assess the Impact of Anti-MCV and the Anti-cyclic-citrullinated Peptide Antibody (Anti-CCP) Status on the Management of Irish Patients With Early RAAbbVie (prior sponsor, Abbott) · NCT01078597
- COMPLETEDAnalysis of Foxp3 and Vimentin Expression in Renal Transplant RecipientAssistance Publique - Hôpitaux de Paris · NCT01443013
- UNKNOWNThe Role and Mechanism of Vimentin in Sepsis PatientsPeking Union Medical College Hospital · NCT03253146
- PHASE2RECRUITINGThe Role of Simvastatin in the Epithelial-Mesenchymal Transition Process of Breast CancerIndonesia University · NCT05550415
- UNKNOWNDiagnostic Utility of Anti MCV Antibodies,Anti CCPantibodies and RF in RAAssiut University · NCT03224377
~7 min read
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
thumb|328px|Immunofluorescence staining pattern of vimentin antibodies. Produced by incubating vimentin primary antibodies and FITC labelled secondary antibodies with HEp-20-10 cells.
Vimentin is a structural protein that in humans is encoded by the VIM gene. Its name comes from the Latin vimentum, meaning an osier, withy (array of flexible rods).