Structure via PubChem · Public domain (PubChem)
YM348
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YM-348 is an indazolethylamine derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor. It has thermogenic and anorectic effects in animal studies, making it potentially useful for the treatment of obesity.
In the Vinony graph
Within Vinony's link graph, YM348 is referenced by 1,587 other articles, and connects out to N-methylserotonin, glaucine and azasetron.
It is catalogued under topics including Benzofurans, Chemical pages without DrugBank identifier and Drugs missing an ATC code.
Its subject is documented across 4 Wikipedia language editions.
Chemical data
- Formula
- C14H17N3O
- Molecular weight
- 243.3 g/mol
- IUPAC name
- (2S)-1-(7-ethylfuro[2,3-g]indazol-1-yl)propan-2-amine
- SMILES
- CCC1=CC2=C(O1)C=CC3=C2N(N=C3)C[C@H](C)N
- InChIKey
- QLOOWOVVZLBYHU-VIFPVBQESA-N
- XLogP
- 2.2
- Polar surface area
- 57 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 243.137162
Show 4 more facts
- chemical formula
- C₁₄H₁₇N₃O
- isomeric SMILES
- CCC1=CC2=C(O1)C=CC3=C2N(N=C3)C[C@H](C)N
- canonical SMILES
- CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N
- Commons category
- YM-348
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
YM-348 is an indazolethylamine derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor. It has thermogenic and anorectic effects in animal studies, making it potentially useful for the treatment of obesity.
== See also == Indazolethylamine Substituted tryptamine § Related compounds AL-34662 AL-38022A O-Methyl-AL-34662 Ro60-0175 VER-3323
Excerpted from Wikipedia’s “YM348” article, available under the CC BY-SA 4.0 licence.