zoledronic acid

Also known as ZOL, ZOL446, CGP-42446, CGP-42446A, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid, (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid, zoledronic acid anhydrous, Zol

chemical compound

Chemical data

Formula: C5H10N2O7P2
Molecular weight: 272.09 g/mol
IUPAC name: (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
SMILES: C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChIKey: XRASPMIURGNCCH-UHFFFAOYSA-N
XLogP: -4.3
Polar surface area: 153 Å²
H-bond donors: 5
H-bond acceptors: 8
Formal charge: 0

via PubChem

Research

6,636 papers

Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2001
Zoledronic acid and fracture risk: a meta-analysis of 12 randomized controlled trials.European review for medical and pharmacological sciences · 2021
Zoledronic acid.Drugs · 2001
Zoledronic acid for the treatment of prostate cancer.Expert opinion on pharmacotherapy · 2019
Zoledronic Acid: Pleiotropic Anti-Tumor Mechanism and Therapeutic Outlook for Osteosarcoma.Current drug targets · 2018

via PubMed

Wikidata facts

Mass: 271.996

Show 5 more facts

chemical formula: C₅H₁₀N₂O₇P₂
Commons category: Zoledronic acid
canonical SMILES: C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
World Health Organisation international non-proprietary name: zoledronic acid
defined daily dose: 4

Sources (8)

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