clodronic acid

Also known as Dichloromethylene-1,1-bisphosphonic acid, (Dichloromethylene)diphosphonic acid, (Dichloromethylene)bisphosphonic acid, (Dichloro-phosphono-methyl)-phosphonic acid, Dichloromethanediphosphonic acid, Dichloromethylene-1,1-diphosphonic acid, Dichloromethylidene diphosphonate, Clodronsaeure

chemical compound

In the Vinony graph

Within Vinony's link graph, clodronic acid is referenced by 32 other articles, and connects out to nitrogen, calcium and digital object identifier.

It is catalogued under topics including Bisphosphonates, Drugboxes which contain changes to watched fields and ECHA InfoCard ID from Wikidata.

Its subject is documented across 11 Wikipedia language editions.

Chemical data

Formula: CH4Cl2O6P2
Molecular weight: 244.89 g/mol
IUPAC name: [dichloro(phosphono)methyl]phosphonic acid
SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl
InChIKey: ACSIXWWBWUQEHA-UHFFFAOYSA-N
XLogP: -2.1
Polar surface area: 115 Å²
H-bond donors: 4
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: bone disease, brachial plexus neuropathy

via ChEMBL · EBI

Research

1,845 papers

Clodronic acid formulations available in Europe and their use in osteoporosis: a review.Clinical drug investigation · 2009
Clodronic acid in the treatment of postmenopausal osteoporosis.Clinical drug investigation · 2007
[Use of clodronic acid in mineral metabolism conditions: state of the art in 2000].Minerva medica · 2001
Clodronate.Bone · 2021
Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial.The Lancet. Oncology · 2011

via PubMed

Wikidata facts

Subclass of: bisphosphonate
Has part: carbon
Mass: 243.886016
Has use: medication

Show 3 more facts

chemical formula: CH₄Cl₂O₆P₂
canonical SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl
World Health Organisation international non-proprietary name: clodronic acid

Sources (3)

via Wikidata · CC0