Structure via PubChem · Public domain (PubChem)
zonisamide
Sign in to saveAlso known as AD-810, CI-912, PD-110843, Zonegran®, 1,2-Benzisoxazole-3-methanesulfonamide, 3-(Sulfamoylmethyl)-1,2-benzisoxazole, Zonisamida
Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease. Chemically it is a sulfonamide. It serves as an anticonvulsant used primarily as an adjunctive therapy in adults with Parkinson's disease, partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic and generalized tonic clonic seizure. Despite this it is also sometimes used as a monotherapy for partial-onset seizures.
Chemical data
- Formula
- C8H8N2O3S
- Molecular weight
- 212.23 g/mol
- IUPAC name
- 1,2-benzoxazol-3-ylmethanesulfonamide
- SMILES
- C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
- InChIKey
- UBQNRHZMVUUOMG-UHFFFAOYSA-N
- XLogP
- 0.2
- Polar surface area
- 94.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,787 papers- Zonisamide add-on therapy for focal epilepsy.The Cochrane database of systematic reviews · 2020
- Zonisamide for essential tremor.The Cochrane database of systematic reviews · 2017
- Zonisamide in Parkinson's disease: a current update.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
- Zonisamide.Epilepsy research. Supplement · 1991
- Zonisamide add-on therapy for focal epilepsy.The Cochrane database of systematic reviews · 2018
via PubMed
Wikidata facts
- Subclass of
- sulfonamide
- Mass
- 212.026
- Has use
- medication
Show 7 more facts
- chemical formula
- C₈H₈N₂O₃S
- medical condition treated
- migraine
- canonical SMILES
- C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
- World Health Organisation international non-proprietary name
- zonisamide
- defined daily dose
- 0.2
- subject has role
- antioxidant
- Commons category
- Zonisamide
Sources (6)
via Wikidata · CC0
~5 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Epilepsy
- Parkinson's disease
- Adverse effects
- Interactions
- Mechanism of action
- Pharmacokinetics
- Absorption
- Metabolism
- History
- Research
- Tardive dyskinesia
- Obesity
- Migraine
- Bipolar depression
- References
Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease. Chemically it is a sulfonamide. It serves as an anticonvulsant used primarily as an adjunctive therapy in adults with Parkinson's disease, partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic and generalized tonic clonic seizure. Despite this it is also sometimes used as a monotherapy for partial-onset seizures.
In 2020, it was the 276th most commonly prescribed medication in the United States, with more than 1million prescriptions.
Excerpted from Wikipedia’s “zonisamide” article, available under the CC BY-SA 4.0 licence.