Structure via PubChem · Public domain (PubChem)
زونیساماید
Sign in to saveAlso known as AD-810, CI-912, PD-110843, Zonegran®, 1,2-Benzisoxazole-3-methanesulfonamide, 3-(Sulfamoylmethyl)-1,2-benzisoxazole, Zonisamide, Zonisamida
Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease. Chemically it is a sulfonamide. It serves as an anticonvulsant used primarily as an adjunctive therapy in adults with Parkinson's disease, partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic and generalized tonic clonic seizure. Despite this it is also sometimes used as a monotherapy for partial-onset seizures.
Chemical data
- Formula
- C8H8N2O3S
- Molecular weight
- 212.23 g/mol
- IUPAC name
- 1,2-benzoxazol-3-ylmethanesulfonamide
- SMILES
- C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
- InChIKey
- UBQNRHZMVUUOMG-UHFFFAOYSA-N
- XLogP
- 0.2
- Polar surface area
- 94.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2000
- Admin. routes
- oral
- Indications
- epilepsy, eating disorder, essential tremor, Seizure
via ChEMBL · EBI
Research
1,787 papers- Zonisamide add-on therapy for focal epilepsy.The Cochrane database of systematic reviews · 2020
- Zonisamide for essential tremor.The Cochrane database of systematic reviews · 2017
- Zonisamide in Parkinson's disease: a current update.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
- Zonisamide.Epilepsy research. Supplement · 1991
- Zonisamide add-on therapy for focal epilepsy.The Cochrane database of systematic reviews · 2018
via PubMed
Wikidata facts
- Subclass of
- sulfonamide
- Mass
- 212.026
- Has use
- medication
Show 7 more facts
- chemical formula
- C₈H₈N₂O₃S
- medical condition treated
- migraine
- canonical SMILES
- C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
- World Health Organisation international non-proprietary name
- zonisamide
- defined daily dose
- 0.2
- subject has role
- antioxidant
- Commons category
- Zonisamide
Sources (6)
via Wikidata · CC0