levomepromazine
Also known as Levoprome®, methotrimeprazine, Nosinan®, Nozinan®, RP-7044, SK&F-5116, 2-Methoxytrimeprazine
Levomepromazine, also known as methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency antipsychotic (approximately half as potent as chlorpromazine) with strong analgesic, hypnotic and antiemetic properties that are primarily used in palliative care.
Chemical data
- Formula
- C19H24N2OS
- Molecular weight
- 328.5 g/mol
- IUPAC name
- (2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
- SMILES
- C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C
- InChIKey
- VRQVVMDWGGWHTJ-CQSZACIVSA-N
- XLogP
- 4.7
- Polar surface area
- 41 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1,106 papers~6 min read
Article
5 sectionsContents
- Medical uses
- Adverse effects
- History
- References
- External links
Levomepromazine, also known as methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency antipsychotic (approximately half as potent as chlorpromazine) with strong analgesic, hypnotic and antiemetic properties that are primarily used in palliative care.
Serious side effects include tardive dyskinesia, akathisia, abnormalities in the electrical cycle of the heart, low blood pressure and the potentially fatal neuroleptic malignant syndrome.