Structure via PubChem · Public domain (PubChem)
levomepromazine
Sign in to saveAlso known as Levoprome®, methotrimeprazine, Nosinan®, Nozinan®, RP-7044, SK&F-5116, 2-Methoxytrimeprazine
Levomepromazine, also known as methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency antipsychotic (approximately half as potent as chlorpromazine) with strong analgesic, hypnotic and antiemetic properties that are primarily used in palliative care.
Chemical data
- Formula
- C19H24N2OS
- Molecular weight
- 328.5 g/mol
- IUPAC name
- (2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
- SMILES
- C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C
- InChIKey
- VRQVVMDWGGWHTJ-CQSZACIVSA-N
- XLogP
- 4.7
- Polar surface area
- 41 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1,106 papers- Levomepromazine for schizophrenia.The Cochrane database of systematic reviews · 2010
- Levomepromazine for schizophrenia.Schizophrenia bulletin · 2012
- Focus on levomepromazine.Current medical research and opinion · 2004
- Levomepromazine for nausea and vomiting in palliative care.The Cochrane database of systematic reviews · 2015
- Levomepromazine (methotrimeprazine) and the last 48 hours.Hospital medicine (London, England : 1998) · 1999
via PubMed
~6 min read
Encyclopedic overview
5 sectionsContents
- Medical uses
- Adverse effects
- History
- References
- External links
Levomepromazine, also known as methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency antipsychotic (approximately half as potent as chlorpromazine) with strong analgesic, hypnotic and antiemetic properties that are primarily used in palliative care.
Serious side effects include tardive dyskinesia, akathisia, abnormalities in the electrical cycle of the heart, low blood pressure and the potentially fatal neuroleptic malignant syndrome.
Excerpted from Wikipedia’s “levomepromazine” article, available under the CC BY-SA 4.0 licence.