ACIN1

Also known as ACINUS, ACN, fSAP152, apoptotic chromatin condensation inducer 1

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.

In the Vinony graph

Within Vinony's link graph, ACIN1 is referenced by 3 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 14 and Human proteins.

Its subject is documented across 7 Wikipedia language editions.

Gene data

ACIN1

Name: apoptotic chromatin condensation inducer 1
Type: protein-coding
Position: 23,058,561–23,095,614 (−)
Aliases: ACINUS, ACN, fSAP152
Ensembl: ENSG00000100813
RefSeq RNA: NM_001164814.2, NM_001164815.2, NM_001164816.2, NM_001164817.2, NM_001386863.1
RefSeq protein: NP_001158286.2, NP_001158287.2, NP_001158288.1, NP_001158289.1, NP_001373792.1

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].