Structure via PubChem · Public domain (PubChem)
acipimox
Sign in to saveAcipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent. It reduces triglyceride levels and increases HDL cholesterol. It may have less marked adverse effects than niacin, although it is unclear whether the recommended dose is as effective as standard doses of niacin.
Chemical data
- Formula
- C6H6N2O3
- Molecular weight
- 154.12 g/mol
- IUPAC name
- 5-methyl-4-oxidopyrazin-4-ium-2-carboxylic acid
- SMILES
- CC1=CN=C(C=[N+]1[O-])C(=O)O
- InChIKey
- DJQOOSBJCLSSEY-UHFFFAOYSA-N
- XLogP
- -1
- Polar surface area
- 75.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- metabolic syndrome, heart failure, bulimia nervosa, cardiovascular disease
via ChEMBL · EBI
Research
358 papers- Acipimox inhibits human carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry · 2022
- Acipimox--a nicotinic acid analogue for hyperlipidaemia.Drug and therapeutics bulletin · 1991
- Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.The Journal of clinical endocrinology and metabolism · 2019
- The lipolysis inhibitor acipimox reverses the cardiac phenotype induced by electronic cigarettes.Scientific reports · 2023
- Severe drug-induced liver injury from acipimox and telmisartan co-administration: A case report and review of literature.Medicine · 2025
via PubMed
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 154.037842
- Has use
- medication
Show 4 more facts
- chemical formula
- C₆H₆N₂O₃
- canonical SMILES
- CC1=CN=C(C=[N+]1[O-])C(=O)O
- subject has role
- hypolipidemic
- Commons category
- Acipimox
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Contraindications
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- References
Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent. It reduces triglyceride levels and increases HDL cholesterol. It may have less marked adverse effects than niacin, although it is unclear whether the recommended dose is as effective as standard doses of niacin.
==Contraindications== Contraindications are peptic ulcers, acute bleeding, recent heart attack, acute decompensated heart failure, and severe chronic kidney disease.
Excerpted from Wikipedia’s “acipimox” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0