colestipol
Also known as Epichlorohydrin-tetraethylenepentamine polymer, Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane, Colestipolum
Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL). It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.
Research
568 papers- Colestipol.2006
- Colestipol.2012
- Colestipol.2026
- Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia.Drugs · 1980
- Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis.Annals of internal medicine · 1982
via PubMed
Article
5 sectionsContents
- Side effects
- Interactions
- Contraindications
- Chemistry
- Notes and references
Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL). It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.
Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.