colestipol

Also known as Epichlorohydrin-tetraethylenepentamine polymer, Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane, Colestipolum

Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL). It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.

Research

568 papers

Colestipol.2006
Colestipol.2012
Colestipol.2026
Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia.Drugs · 1980
Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis.Annals of internal medicine · 1982

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Wikidata facts

Mass: 281.198238

Show 4 more facts

chemical formula: C₁₁H₂₈ClN₅O
canonical SMILES: C1C(O1)CCl.C(CNCCNCCNCCN)N
defined daily dose: 20
NCI Thesaurus ID: C81540

Sources (3)

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Article

5 sections

Contents

Side effects
Interactions
Contraindications
Chemistry
Notes and references

Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.