Structure via PubChem · Public domain (PubChem)
Colestipol
Sign in to saveAlso known as Epichlorohydrin-tetraethylenepentamine polymer, Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane, Colestipolum
composto químico
Chemical data
- Formula
- C11H28ClN5O
- Molecular weight
- 281.83 g/mol
- IUPAC name
- N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;2-(chloromethyl)oxirane
- SMILES
- C1C(O1)CCl.C(CNCCNCCNCCN)N
- InChIKey
- GMRWGQCZJGVHKL-UHFFFAOYSA-N
- Polar surface area
- 101 Ų
- H-bond donors
- 5
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Unknown
via ChEMBL · EBI
Research
568 papers- Colestipol.2006
- Colestipol.2012
- Colestipol.2026
- Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia.Drugs · 1980
- Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis.Annals of internal medicine · 1982
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 281.198238
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₁H₂₈ClN₅O
- canonical SMILES
- C1C(O1)CCl.C(CNCCNCCNCCN)N
- defined daily dose
- 20
- NCI Thesaurus ID
- C81540
Sources (3)
via Wikidata · CC0
Article · Português
Colestipol é um sequestrador de ácidos biliares. Ele atua no intestino promovendo a interceptação de sais biliares, e impedindo-os de serem reabsorvidos. Isso leva à diminuição da recirculação entero-hepática de sais biliares, aumento da síntese de novos sais biliares pelo fígado, diminuição do colesterol, aumento da expressão do receptor de LDL, e diminuindo o LDL no sangue.
Abstract from DBpedia / Wikipedia · CC BY-SA
Gallery (4)
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via Wikidata sitelinks · CC0