ADGRG3
Sign in to saveAlso known as PB99, PGR26, GPR97, adhesion G protein-coupled receptor G3
G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Gene data
ADGRG3- Name
- adhesion G protein-coupled receptor G3
- Type
- protein-coding
- Position
- 57,668,106–57,689,378 (+)
- Aliases
- GPR97, PB99, PGR26
- Ensembl
- ENSG00000182885
- RefSeq RNA
- NM_001308360.2, NM_170776.5, XM_005255842.5, XM_006721170.5, XM_011522953.4
- RefSeq protein
- NP_001295289.1, NP_740746.4, XP_005255899.1, XP_006721233.1, XP_011521255.1
Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
~2 min read
Encyclopedic overview
4 sectionsContents
- Signaling
- Function
- References
- External links
G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
GPR97 is expressed in human granulocytes and endothelial cells of the vasculature as well as in mouse granulocytes, monocytes, macrophages, and dendritic cells.
Excerpted from Wikipedia’s “ADGRG3” article, available under the CC BY-SA 4.0 licence.