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GeneQ18037144· pop 5· linked from 8 articles

ADNP

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Also known as ADNP1, MRD28, HVDAS, activity-dependent neuroprotector homeobox, activity dependent neuroprotector homeobox

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 8 inbound references to ADNP, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 20.

Vinony links it to 4 Wikipedia language editions.

Gene data

ADNP

Name: activity dependent neuroprotector homeobox
Type: protein-coding
Position: 50,854,048–50,931,437 (−)
Aliases: ADNP1, HVDAS, MRD28
Ensembl: ENSG00000101126
RefSeq RNA: NM_001282531.3, NM_001282532.2, NM_001347511.2, NM_001439000.1, NM_001439001.1
RefSeq protein: NP_001269460.1, NP_001269461.1, NP_001334440.1, NP_001425929.1, NP_001425930.1

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II short-term memory response to carbohydrate regulation of gene expression regulation of gene expression negative regulation of gene expression positive regulation of neuron projection development

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding chromatin binding copper ion binding

Cellular component

chromatin extracellular region nucleus nucleus nucleoplasm chromosome chromosome axon

Pathways

Chromatin organization Chromatin organization ATP-dependent chromatin remodelers ATP-dependent chromatin remodelers CHD chromatin remodelers CHD chromatin remodelers ChAHP complex assembly ChAHP complex assembly CHD3, CHD4, CHD5 subfamily CHD3, CHD4, CHD5 subfamily

via MyGene.info

Gene · Ensembl

activity dependent neuroprotector homeobox

Symbol: ADNP
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:50,854,048-50,931,437
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 7617
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23394
genomic end: 50931437
genomic start: 50888916
chromosome: human chromosome 20
cytogenetic location: 20q13.13
genetic association: Helsmoortel-Van Der Aa syndrome

Sources (9)

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 20