AM-404
Sign in to saveAlso known as N-arachidonoylphenolamine, AM404
AM404, also known as '''N-arachidonoylphenolamine''', is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action and anticonvulsant effects. Chemically, it is the amide formed from 4-aminophenol and arachidonic acid. AM404 is one of the AM cannabinoids discovered by Alexandros Makriyannis and his team.
Wikidata facts
- Mass
- 395.282
Show 3 more facts
- chemical formula
- C₂₆H₃₇NO₂
- canonical SMILES
- CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O
- isomeric SMILES
- CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1=CC=C(C=C1)O
Sources (2)
via Wikidata · CC0
~4 min read
Article
8 sectionsContents
- Pharmacokinetics
- Pharmacodynamics
- CB<sub>1</sub> and CB<sub>2</sub>
- Endocannabinoid concentration
- TRPV1
- Sodium channels
- See also
- References
AM404, also known as '''N-arachidonoylphenolamine', is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action and anticonvulsant effects. Chemically, it is the amide formed from 4-aminophenol and arachidonic acid. AM404 is one of the AM cannabinoids discovered by Alexandros Makriyannis and his team.
== Pharmacokinetics == AM404 is found in the brains of animals and cerebrospinal fluid of humans taking paracetamol. It is produced from 4-aminophenol by the action of FAAH.