AM-404
Sign in to saveAlso known as N-arachidonoylphenolamine, AM404
AM404, also known as '''N-arachidonoylphenolamine''', is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action and anticonvulsant effects. Chemically, it is the amide formed from 4-aminophenol and arachidonic acid. AM404 is one of the AM cannabinoids discovered by Alexandros Makriyannis and his team.
~4 min read
Encyclopedic overview
8 sectionsContents
- Pharmacokinetics
- Pharmacodynamics
- CB<sub>1</sub> and CB<sub>2</sub>
- Endocannabinoid concentration
- TRPV1
- Sodium channels
- See also
- References
AM404, also known as '''N-arachidonoylphenolamine', is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action and anticonvulsant effects. Chemically, it is the amide formed from 4-aminophenol and arachidonic acid. AM404 is one of the AM cannabinoids discovered by Alexandros Makriyannis and his team.
== Pharmacokinetics == AM404 is found in the brains of animals and cerebrospinal fluid of humans taking paracetamol. It is produced from 4-aminophenol by the action of FAAH.
Excerpted from Wikipedia’s “AM-404” article, available under the CC BY-SA 4.0 licence.