ASB2

Also known as ASB-2, ankyrin repeat and SOCS box containing 2

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.

In the Vinony graph

Within Vinony's link graph, ASB2 is referenced by 2 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ASB2

Name: ankyrin repeat and SOCS box containing 2
Type: protein-coding
Position: 93,933,783–93,978,831 (−)
Aliases: ASB-2
Ensembl: ENSG00000100628
RefSeq RNA: NM_001202429.2, NM_016150.5, XM_005267758.4, XM_011536834.4, XM_011536835.4
RefSeq protein: NP_001189358.1, NP_057234.2, XP_005267815.1, XP_011535136.1, XP_011535137.1

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

Gene Ontology

Biological process

heart looping ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process signal transduction skeletal muscle atrophy protein ubiquitination protein ubiquitination actin cytoskeleton organization

Molecular function

protein binding ubiquitin protein ligase activity cullin family protein binding

Cellular component

ubiquitin ligase complex ubiquitin ligase complex stress fiber nucleus cytoplasm cytosol cytosol Z disc

Pathways

Adaptive Immune System Immune System Metabolism of proteins Post-translational protein modification Neddylation Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation

via MyGene.info

Gene · Ensembl

ankyrin repeat and SOCS box containing 2

Symbol: ASB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:93,933,783-93,978,831
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 69202
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/51676
chromosome: human chromosome 14
genomic start: 93934166
genomic end: 93976739
cytogenetic location: 14q32.12
expressed in: right coronary artery

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.

The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

Excerpted from Wikipedia’s “ASB2” article, available under the CC BY-SA 4.0 licence.