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GeneQ18030580· pop 5· linked from 12 articles

PLCB2

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Also known as PLC-beta-2, phospholipase C beta 2

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.

In the Vinony graph

Within Vinony's link graph, PLCB2 is referenced by 12 other articles, and connects out to PubMed, human chromosome 15 and Ensembl genome database project.

It is catalogued under topics including EC 3.1.4 and Genes on human chromosome 15.

Its subject is documented across 5 Wikipedia language editions.

Gene data

PLCB2

Name: phospholipase C beta 2
Type: protein-coding
Position: 40,278,176–40,307,965 (−)
Aliases: PLC-beta-2
Ensembl: ENSG00000137841
RefSeq RNA: NM_001284297.2, NM_001284298.2, NM_001284299.2, NM_004573.3, XM_017022314.3
RefSeq protein: NP_001271226.1, NP_001271227.1, NP_001271228.1, NP_004564.2, XP_016877803.1

The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].

Gene Ontology

Biological process

detection of chemical stimulus involved in sensory perception of bitter taste lipid metabolic process phospholipid metabolic process signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway

Molecular function

phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity C-type glycerophospholipase activity C-type glycerophospholipase activity calcium ion binding

Cellular component

cytoplasm cytoplasm cytosol G-protein beta/gamma-subunit complex neuronal dense core vesicle

Pathways

Inositol phosphate metabolism - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)Phosphatidylinositol signaling system - Homo sapiens (human)Sphingolipid signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

phospholipase C beta 2

Symbol: PLCB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:40,278,176-40,307,965
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein PLCB2 PDB 2fju.png

Show 7 more facts

HomoloGene ID: 20957
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5330
genomic end: 40600136
genomic start: 40570377
chromosome: human chromosome 15
cytogenetic location: 15q15.1

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.

== Function ==

Excerpted from Wikipedia’s “PLCB2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

EC 3.1.4 Genes on human chromosome 15