PDE4B
Sign in to saveAlso known as DPDE4, PDEIVB, phosphodiesterase 4B
'''cAMP-specific 3',5'-cyclic phosphodiesterase 4B' is an enzyme that in humans is encoded by the PDE4B'' gene.
In the Vinony graph
Within Vinony's link graph, PDE4B is referenced by 449 other articles, and connects out to PubMed, Ensembl genome database project and light.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 6 Wikipedia language editions.
Gene data
PDE4B- Name
- phosphodiesterase 4B
- Type
- protein-coding
- Position
- 65,792,514–66,374,582 (+)
- Aliases
- DPDE4, PDEIVB
- Ensembl
- ENSG00000184588
- RefSeq RNA
- NM_001037339.2, NM_001037340.3, NM_001037341.2, NM_001297440.2, NM_001297441.1
- RefSeq protein
- NP_001032416.1, NP_001032417.1, NP_001032418.1, NP_001284369.1, NP_001284370.1
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
phosphodiesterase 4B
- Symbol
- PDE4B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:65,792,514-66,374,582
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PDE4B PDB 1f0j.png
Show 8 more facts
- HomoloGene ID
- 1953
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5142
- genomic end
- 66840259
- genomic start
- 66258197
- chromosome
- human chromosome 1
- cytogenetic location
- 1p31.3
- expressed in
- pons
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Clinical relevance
- Inhibitors
- References
- Further reading
'''cAMP-specific 3',5'-cyclic phosphodiesterase 4B' is an enzyme that in humans is encoded by the PDE4B'' gene.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Excerpted from Wikipedia’s “PDE4B” article, available under the CC BY-SA 4.0 licence.