PDE4B

Also known as DPDE4, PDEIVB, phosphodiesterase 4B

'''cAMP-specific 3',5'-cyclic phosphodiesterase 4B' is an enzyme that in humans is encoded by the PDE4B'' gene.

Gene data

PDE4B

Name: phosphodiesterase 4B
Type: protein-coding
Position: 65,792,514–66,374,579 (+)
Aliases: DPDE4, PDEIVB
Ensembl: ENSG00000184588
RefSeq RNA: NM_001037339.2, NM_001037340.3, NM_001037341.2, NM_001297440.2, NM_001297441.1
RefSeq protein: NP_001032416.1, NP_001032417.1, NP_001032418.1, NP_001284369.1, NP_001284370.1

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].

Pathways

Purine metabolism - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Opioid Signalling Signal Transduction DARPP-32 events Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events

via MyGene.info

Gene · Ensembl

phosphodiesterase 4B

Symbol: PDE4B
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:65,792,514-66,374,582
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PDE4B PDB 1f0j.png

Show 5 more facts

HomoloGene ID: 1953
exact match: identifiers.org/ncbigene/5142
genomic end: 66840259
genomic start: 66258197
cytogenetic location: 1p31.3

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Clinical relevance
Inhibitors
References
Further reading

'''cAMP-specific 3',5'-cyclic phosphodiesterase 4B' is an enzyme that in humans is encoded by the PDE4B'' gene.

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.